Effect of Rhus coriaria L. methanolic fruit extract on woundhealing in diabetic and non-diabetic rats Ahmad Za’al Alsarayreh PhD1,2 | Sawsan Atallah Oran PhD1 |Jumah Mutie Shakhanbeh PhD  Journal of cosmetic dermatology Received: 8 September 2021 | Revised: 2 November 2021 | Accepted: 1 December 2021   Abstract : Aim: This study assessed the effects of topical application of R. coriaria extract on therate of wound closure. The rate of wound contraction was used to assess the woundhealing efficacy of the R. coriaria fruit methanolic extract.Methods: Using excision and burn model of wound repair in diabetic male Wistar rats.Also, hydroxyproline, collagen content, and proinflammatory and anti-inflammatorycytokines levels were determined in this study.Results: During the early wound healing phase, interleukin 6 (IL-6) levels were foundto be decreased by R. coriaria treatment and increased the level of interleukin 10(IL-10). Increased wound contraction augmented with hydroxyproline and collagencontent, supporting the early wound healing exhibited by R. coriaria. The epithelialization, neovascularization and enhanced hydroxyproline and collagen expression werestrongly associated with the healing pattern.Conclusion: This study indicating that R. coriaria methanolic fruit extract has a potentwound healing capacity. And may be effective in the topical therapy of wound healing.