This study aims to investigate the impact of knowledge management processes (KMPs) on business transformation (BT) as mediated by IT agility. The population of the study is the lecturers and employees of Mutah University with a total of 305 participants. A questionnaire is adopted to conduct the study then the data is analyzed according toSPSS modeling technique in order to determine what the level of the existing relationship between KMPs and BT as mediated by IT agility. Finally, the study concludes with main findings and recommendations are related to confirming the two main hypotheses of the research that are related to testing if there are relationships between the KMPs (represented by four surrogate measures, namely, knowledge creation, knowledge storage, knowledge sharing and knowledge application) and BT, as well as if the KMPs is related to the BT as mediated by IT agility.