This study employs a quantitative approach to investigate the relationship between E-learning and Organizational Excellence in UAE universities. The study focuses on 250 senior and middle ad-ministrators from public universities selected through a convenience sampling method. The ad-vanced statistical tools SPSS and AMOS were used to analyze the research data through Structural Equation Modeling (SEM). The findings reveal the impact of e-learning dimensions–TechnicalKnowledge and Management Willingness—on Organizational Excellence. Additionally, the study delves into moderation effects, revealing that Gender, Age, Educational Level, and Experi-ence play pivotal roles in influencing perceptions of e-learning among senior and middle admin-istrators at UAE public universities. This research contributes to the understanding of how e-learning impacts Organizational Excellence within the UAE university landscape while also high-lighting the crucial moderating roles of demographic variables. These findings offer valuable in-sights for educational institutions aiming to optimize e-learning strategies and enhance organiza-tional performance.