Abstract :

Background: The worldwide pandemic of Coronavirus disease 2019 emerged in December 2019 in Wuhan, China. Early identification of immunological biomarkers isa critical step for the disease diagnosis and progression in pursuance of classifying high-risk patients within the dearth of relevant information. Material and method: In a retrospective study, the laboratory finding of 98 COVID19 positively diagnosed patientswith ages ranged from 9 up to 77 years and administered to Prince Hamza Hospital, Amman, Jordan were used in the study. We have adopted the immunological parameters of WBCs, neutrophils, monocyte, basophils, D-dimer,CRP,and ESR as markers for anticipated diagnostic indicators. Results: Laboratory findings of COVID-19 showed that total WBCs might not be affected with SARS-CoV-2 in the initial phase of the disease. While the lymphocyte, eosinophil,basophil and CRP gave a primary indication about the COVID-19 infection through lymphopenia, eosinopenia, basopenia and an increase in the CRP value.The results of total WBC give a highly significant positive correlation with neutrophils (p<0.05), negative correlation with eosinophil and ESR, and significant positive correlation with monocyte and CRP (p<0.05). The age of the patient gave a negative correlation with lymphocyte, a highly significant negative correlation with eosinophil (p<0.01), and a significant positive correlation with ESR and CRP (p<0.05). Furthermore, The ESR gave a significant positive correlation with age and CRP (p<0.05), negative correlation with total WBCs, neutrophils, monocyte, eosinophil, lymphocyte, and D-dimer. Finally, the D-dimer results gave negative correlations with eosinophil, monocyte, lymphocyte, and ESR. Conclusion: We can summarize from this study that COVID19 patients show lymphopenia, eosinopenia, basopenia and elevations in CRP levels. The increase in age harms the immunological parameters for COVID 19 patients regardless of gender.