Abstract :

This study aimed to explore the preventive effect of the methanolic extracts of the seeds of Citrullus colocynthis,and the aerial parts of Ruta graveolens and Peganum harmala on the development of secondary infection ofEchinococcus granulosus in vivo. The viable protoscolices were subjected to 40 mg/mL of methanolic extracts ofthe three plants for 4 hours of exposure times in vitro, then injected into male Albino-Wistar rats for 8 months.Compared to the negative control group, R. graveolens methanolic extract showed high significant (p< 0.05)protoscolicidal and preventive effects on the secondary hydatid cysts growth similar to that recorded inalbendazole (ABZ) drug. However, P. harmala and C. colocynthis methanolic extracts showed low preventiveeffects on the secondary hydatid cysts' growth. The preventive effects were represented by the reduction in theinfection rate, cysts number, size, and weight. In addition to the high significant changes (p< 0.05) in values ofhematological and biochemical parameters, elevation of gamma interferon (IFN-γ) levels and decline ofinterleukin-10 (IL-10) and IL-4 cytokines compared to the negative control group (5) (PDF) The in vivo preventive effect of some medicinal plant extracts on the development of hydatid cyst infection. Available from:

https://www.researchgate.net/publication/371181597_The_in_vivo_preventive_effect_of_some_medicinal_plant_extracts_on_the_development_of_hydatid_cyst_infection [accessed Jun 04 2023].