Abstract :

This study aimed to see how effective Globularia arabica and Malva slyvestries-based cream formulations were athealing scald burn wounds in rats. Depending on ointment, preparations of 1%, 5%, and 10% w/w were created.For comparison, an ointment base and a regular burn cream composed soframycine were utilized. Rats introduceda burn by solidifying equipment at 100°C on a 14-mm2 shaved dorsal region. A deep second-degree burn wascreated, and the percentage of wound contraction was measured over the next 15 days. The rats were euthanizedon days 8 and 15, and histological slides were prepared using hematoxylin and eosin staining. Compared to thecontrol group, there was a substantial increase in wound contraction and a significant decrease in the duration ofepithelialization in the based ointment-treated groups. However, as paralleled to Globularia arabica, significant(P < .05) results were observed with 10% Globularia arabica cream, whereas Malva slyverstries indicate minimalhealing. Soframycine causes a substantial increase in wound contraction (P < .05). Soframycine cream with 10%Globularia arabica therapy resulted in practically complete re-epithelialization and re-structuring of woundtissue on histological examination, whereas Malva slyversries treatment resulted in low epithelization duringtreatment days. The findings suggest that Globularia arabica-based cream has the wound-healing capability