Abstract :

Article title Efficacy of methanolic extracts of some medicinal plants on wound healing in diabetic rats Article author or authors Ahmad Z. Alsarayreh, Sawsan A. Oran, Jumah M. Shakhanbeh, Khaled M. Khleifat,Yaseen T. Al Qaisi, Ibrahim I. Alfarrayeh, Ayah M. Alkaramseh Name of journal and date of publication Heliyon 2022 Article abstract. Background: One of the primary health concerns for diabetes individuals is wounds. The used drugs have severalside effects, urging the need for new natural sources for therapeutics.Materials and methods: This study was designed to estimate the wound healing potential of the methanolic extractof Globularia arabica and Malva sylvestris leaves and Rhus coriaria fruits. plant extracts were orally administered tothe rats to determine their effect on the wound-healing process.Results: Plant extracts significantly increased the contraction of the wound in non-diabetic and diabetic rats (P <0.05) and increased the fibroblast's proliferation and migration resulting in a faster healing process. The plantextracts have no cytotoxic effects. The proliferation assay exhibited the lowest cell mortality after treatment withplant extract.Conclusion: These findings may indicate that the methanolic leaf extract of the above plants can be used as newtherapeutics for wound healing in diabetic patients.