Abstract :

Globularia arabica methanolic leaf extract has higher efficacy on burn wound healing in diabetic rats compared to Malva slyvestries methanolic leaf extract Ahmad Z Al-Sarayreh , Khaled M Khleifat , Sa'ed M Al-Dalain , Yousef M Al-Saraireh , Yaseen T Al-Qaisi , Ibrahim I Al-Farrayeh , Samer Y Al-Qaraleh    This study aimed to see how effective Globulari. arabica and Malva. slyvestries-based cream formulations were at healing scald burn wounds in rats. Depending on ointment preparations of 1%, 5%, and 10% w/w were created. For comparison, an ointment base and a regular burn cream composed soframycine were utilized. Rats introduced a burn by solidifying equipment at 100°C on a 14 mm 2 shaved dorsal region. A deep second-degree burn was created, and the percentage of wound contraction was measured over the next 15 days. The rats were euthanized on days 8 and 15, and histological slides were prepared using hematoxylin and eosin staining. Compared to the control group, a substantial increase in wound contraction and a significant decrease in the duration of epithelialization in the based ointment-treated groups. However, as paralleled to Globularia arabica, significant (P < 0.05) results were observed with 10% Globularia. arabica cream, whereas Malva. slyverstries indicate minimal healing. Soframycine causes a substantial increase in wound contraction (P <0.05). Soframycine cream with 10% Globularia arabica therapy resulted in practically complete re-epithelialization and re-structuring of wound tissue on histological examination, whereas Malva slyversries treatment resulted in low epithelization during treatment days. The findings suggest that Globularia arabica-based cream has the wound-healing capability.