The beginning of the year 2019 has changed the face of the world as it was noticeable emergenceof Corona Virus disease (COVID-19). This virus has spread to cover almost all the nations of the world aswell as, and has paralyzed every sector even detailed life of people whom have been requiredcompulsory to stay at home in incarceration. There have been a lot of studies that have required toinvestigate the effect of this pandemic from different standpoints, and to analyze the medicationsbeing applied especially the misuse of antibiotics of different categories, and which have beenalthough many studies found that weak managing of the antibiotic and misusing it has resulted intocatastrophic results ,as ensured many researchers throughout the world. Thus the WHO has informedthe governments that misuse of the antibiotic might be like “pouring the oil on the fire” ,and there is aprerequisite to get antibiotic use to be managed well according to the results that this review hasreached by studying several reports and studies carried out by distinguished researchers throughoutthe globe, and to investigate how using antibiotic to effectively be governed. However, this study willpay attention to how the antibiotic has been misused during the pandemic in many countries. Theobjective of this review is to learn more about researches carried out on the misuse of antibiotic duringthe COVID-19 pandemic.