1. Article title:

Cytochrome 4Z1 expression is correlated with poor prognosis in patients with cervical cancer

2. Article author or authors

Yousef M Al-Saraireh, Fatemah OFO Alshammari, Ahmed MM Youssef, Yahya M Al-Sarayra, Renata A Al-Saraireh, Ghadeer H Al-Muhaisen, Yanal S Al-Mahdy, Ahlam M Al-Kharabsheh, Seham M Abufraijeh, Hamzeh Mohammad Alrawashdeh

3. Name of journal and date of publication

Current Oncology (2021/9/16)

4. Article abstract

Background: cervical cancer is one of the most common malignancies in women worldwide and its management remains challenging and complex. As Cytochrome4Z1 (CYP4Z1) is overexpressed in many tumours, its expression in cervical cancer is unknown. Therefore, the present study aimed to evaluate CYP4Z1 expression in cervical cancers. Methods: CYP4Z1 expression was immunohistochemically assessed in 100 cases of cervical cancers along with ten normal cervix tissues, and the enzyme’s relationship to several clinicopathological features and survival was explored. Results: CYP4Z1 was strongly expressed in 55% of cervical cancer patients. Normal cervix samples were negative for CYP4Z1 expression. Importantly, this expression was significantly found in patients with the late stage of the disease, lymph node metastasis, and high tumour invasion (p < 0.05). Interestingly, CYP4Z1 expression was significantly correlated with shorter survival times of cervical cancer patients. Univariate analysis showed that CYP4Z1 expression, tumour stage, lymph node metastasis, and tumour invasion were significantly correlated with patient survival (p < 0.05). The multivariate analysis revealed that only CYP4Z1 expression and tumour stage were significantly correlated with patient survival (p < 0.05). Conclusions: CYP4Z1 expression is associated with cervical cancer patients’ survival and may serve as an independent predictor of poor prognosis in cervical cancer patients.