This study aims to verify the adolescents’ ability to correctly identify mental health disorders such asdepression and the intention to seek help, which refers to the determinants of Mental HealthLiteracy (MHL). As well as understanding the relationship between MHL and the psychologicalstate associated with depression among adolescents in schools. This study was conducted using across sectional descriptive design and included 450 adolescent students (215 males and 235 females)from public intermediate and secondary schools in southern Jordan, and they were between 13 and16 years old from ten randomly selected schools. Data on sociodemographic characteristics (gender,age, smoking, exposure to bullying, loneliness, parental marital status, and financial statusrepresented by parental income) of participating adolescents were collected through student datafrom school principals and then assessed by the Global Student Health Survey (GSHS). MHL amongadolescents was assessed and measured using the depression vignette and questionnaire of themental health literacy and stigma. The data were analyzed using the Statistical Program for SocialSciences (SPSS) and multivariate binary logistic regression to examine and study the determinantsof MHL. The results were obtained, the most important of which was that the adequate levels ofMHL among adolescents were clearly and directly related to several factors. This was demonstratedby the use of multivariate analysis. The study concluded that the factors that significantly affectedadequate levels of MHL were gender (females), age (older adolescents), non-smoking, and lack ofloneliness. Where the values related to these factors obtained from multivariate analysis were(AOR=1.72; 95% CI 1.15, 2.57), (AOR=1.52; 95% CI 1.04, 2.22), (AOR=1.60; 95% CI 1.09, 3.54),(AOR=1.20; 95% CI 1.12, 1.76), respectively. One of the most important recommendations focusedin this research is to pay attention to addressing the determinants and levels of MHL adequate todevelop a generation of young adolescents who are more aware and free of mental disorders andhave high levels of MHL adequate. ASEAN Journal of Psychiatry, Vol. 24 (1) January, 2023; 1-15.