Abstract Background: Haemophilia is an inherited bleeding disorder. Mothers of children with   haemophilia experience stress, anxiety and different types of burdens that affect their life negatively. Objectives: This study aimed to explore the lived experience of mothers of childrenwith haemophilia.Methods: A descriptive phenomenological design was utilized. The participants were selected purposively from the Jordanian Association for Thalassemia and Hemophilia.Data saturation was achieved by interviewing 20 mothers. Results: Five themes emerged: (1) the challenges related to the diagnosis, the availability and administration of the clotting factors, and the occurrence of the bleedingemergency; (2) physical, social, psychological and financial burden; (3) fear of childdeath and disability; (4) stigmatization; and (5) lack of educational and medical support.Conclusion: Mothers of children with haemophilia suffer from physical, psychologicaland social consequences. Healthcare providers should carry out educational sessionsregarding the importance of support for the family and throughout the life of the child.