Objective:

This study aims to assess the quality of life for parents with a newborn in the neonatal intensive careunit in an end-of-life situation and to investigate the relationship between predictive factors affecting theirquality of life.Designs and methods: A cross-sectional descriptive study was conducted in three different hospitals in Amman,namely, 1) Al-Bashir, 2) Queen Rania Hospital, and 3) King Al Hussein Hospital. A total of 108 eligible parentswere included in this study. Data were collected using a two-part questionnaire. The first part of the questionnaire measured the socio-demographic characteristics of the parents and their newborns, while the second partused the World Health Organization Quality-of-Life Scale to assess the quality-of-life level.Results: The overall perception of the quality of life of parents had a mean of 59.95 (moderate), while the overallperception of health had a mean of 68.52 (high). The results indicated that there are statistically significantdifferences between fathers and mothers in the overall perception of quality of life (P = 0.003); the differencesfavor fathers, with a mean of 67.13. The study found only a relationship between gender as a predictive factorand overall perception of quality of life (P = 0.018). However, no relationship was found between educationallevel, age, family income, and overall perception of quality of life.Conclusion: The study shows disparities in parental perceptions of neonates in end-of-life situations in neonatalcritical care units. A moderately average quality of life was noted, influenced by emotional stress and difficultdecisions.Practical implications: As the parents of newborns admitted to the neonatal intensive care unit have poor qualityof life, healthcare strategies need to be prioritized to maintain parents’ health and well-being and enhance theirability to cope with this situation.