A multicenter study on the perspectives of Jordanian medical students on patient safety Mohammad N. Nofal, Mahmoud M. Al Awayshih, Saleh M. Abualhaj, Ali J. Yousef, Al-hareth A. Mistarihi, Sultan S. Al-Daboubi, Mona M. Abuzaid, Lama R. Rabee, Raya S. Al-Shakhanbeh & Orwa J. Al-Masarwah  Abstract Patient safety is intended to prevent harm or to halt accidents and negative side effects that patients may experience because of various treatment options. The aim of this study is to monitor the responses of medical students towards patient safety issues, introduce the term and practice to medical students, and fill the gap between clinical education and quality control. Medical therapy breakthroughs have resulted in an increase in side effects and hazards. Patient safety should be taught in medical schools from the beginning. This cross-sectional study was conducted in August 2022 at the School of Medicine at Mutah University, Jordan. 468 medical students from all academic years from six different Jordanian medical institutions are participating with their medical schools. all six Jordanian medical schools from different six universities were recruited. A questionnaire was used for collecting data, which was then analyzed using Pearson Chi-square test, ANOVA, and Spearman correlation. coefficient. A total of 454 questionnaires were completed (response rate 97%), and 58.4% of the students demonstrated knowledge about patient safety, and their attitude was enhanced (over 90%). 76.9% of students believe there is a gap between what medical professionals consider “best care” and what is offered daily, and 61.0% believe medical errors are unavoidable. The relationship between the student’s demographic and all knowledge, attitude, and practice was not significant (P > 0.05). Medical students’ inadequate patient safety knowledge exemplifies the failure of unorganized education to keep up with new safety ideas, therefore, it is advised that patient safety topics be covered from the very beginning of the medical school curriculum. This can be achieved through lectures, discussion groups, practice-based learning rounds, case study, simulation, patient tracking and other formats. Scientific Reports volume 15, Article number: 21071 (2025) https://doi.org/10.1038/s41598-025-98113-w