A brain tumor is the abnormal cells that growth in the brain, and it is considered as one of the most dangerous diseases that lead to the cause of death. Diagnosis at early is important for increasing the survival rate from the brain tumors. Specialists can identify the tumors manually, but it is very time and effort consuming, and are subject to human error, especially when dealing with large amounts of images. The automatic identification algorithms-based applications can facilitate the process. This study aimed to investigate the possibility of detecting brain cancer based on images using Deep Learning (DL) techniques and statistical operations. The features were extracted using two models of Convolutional Neural Network (CNN), (VGG-19 and AlexNet), then they were used to generate new datasets for statistical operations. CNN is used to extract features with distinct details from brain MRI images. The data were trained in three different training–testing data splitting ratios. Then, the features were classified based on the KNN, RF, and SVM to find the best accuracy of brain MRI image. At the end, the obtained classification accuracy was in favor of statistical operations especially for Large-Value, and Merge between features using KNN (99.1) and SVM (99.1). The features that extracted used in this study can provide high influence on the classification accuracy. The results across all three training–testing data splitting ratios were almost similar, and this approves that the brain cancer can be identified with high accuracy even if the training dataset sizes were minimal.