The main purpose of using nanofluids in this study is cooling the photovoltaic panels to obtain the best PV performance, such as increasing the efficiency, lifespan and power output. This study used a 2 wt% Al₂O₃/TiO₂ hybrid nanofluid coolant to determine its effects and evaluate them with those of previous studies that used each of Al₂O₃ and TiO₂ at same concentrations. The system, which has been used in this work, consists of three photovoltaic panels having the same specifications but with different methods of cooling in one-pass flow. The first photovoltaic panel PV-1 was cooled by using 2 wt% Al₂O₃/TiO₂ hybrid nanofluid. The second panel PV-2 was cooled by water only, while the third PV-3 was utilized without cooling. Experiments were carried out at various rates of the flow of cooling fluid ranging from (0.5 L/min) - (3 L/min). Results were compared with the reference panel PV-3. The maximum output powers were (46.6, 45.1 and 41.9 W) for cooling by hybrid nanofluid, water only, and uncooled panel, respectively. That manifested an increasing in the output power by 11.2% in comparison with the uncooled panels. The temperature of hybrid nanofluid increased by (9.6 °C) compared with (8.4 °C) for cooling by water only. After using Al₂O₃/Tio₂ hybrid nanofluid, it resulted in the highest increase (17.6%) in the electrical energy efficiency. The comparison with previous researches demonstrated that the optimum performance was attained while cooling the PV panels by using a 2 wt% hybrid nanofluid.