Mutaz Al-Tarawneh,  Mustafa Muheilan, Ziyad Altarawneh International Journal on Engineering Applications (IREA) 9(4), July 2021 DOI:10.15866/irea.v9i4.20616   Abstract : Recent advances in machine learning techniques have significantly influenced the development of early diabetes detection systems. In this paper, different machine learning (ML) algorithms are employed for diabetes detection based on hand movement. The spatial and temporal information for horizontal and vertical hand movement deviations for both diabetic and non-diabetic subjects are obtained using a data acquisition system. A dataset is constructed based on the obtained hand movement information along with other related attributes such as age, gender, weight and vision health. Binary classification of diabetic and non-diabetic subjects is achieved using several machine learning algorithms. These algorithms include Naïve Bayes (NB), Logistic Regression (LR), Linear Discriminate Analysis (LDA), Classification and Regression Tree (CART), k-Nearest Neighbors (KNN), Support Vector Machine (SVM) and Multi-layer Perceptron (MLP).  The considered ML algorithms are evaluated and ranked according to a set of key performance metrics that include accuracy, precision, recall and F-1 score. Algorithm ranking results demonstrate that LR, CART, KNN and MLP algorithms have achieved higher ranking positions as compared to other algorithms. The best ranked ML algorithms are then validated and thoroughly investigated to prove their ability to discriminate between diabetic and non-diabetic subjects. Validation results show that the best-ranked ML algorithms have achieved high classification accuracy, precision, recall and F-1 scores.  Therefore, the considered machine learning algorithms can serve as efficient tools for diabetes detection based on the constructed dataset. Keywords: Diabetes detection; Hand movement; Machine Learning; Neuropathy.