MUSTAFA MUHEILAN, ZIYAD A. AL TARAWNEH Journal of Engineering Science and Technology Vol. 16, No. 2 (2021) 1122 - 1137 Abstract : A computerized setup has been developed and used to quantify deterioration in the hand movement of diabetic subjects, in the form of horizontal hand skew and its associated movement time. The horizontal hand deviation and movement time for diabetics compared to normal subjects were investigated in detail. The test population of this study was a group of females and males of different ages with a total population of 209 controls as well as 50 certified diabetics. The hand movement time was slightly affected by diabetes with a mean value of 5.03 s for diabetic subjects, compared to 4.99 s for controls. The mean values of horizontal deviation (skew) from the vertical track were highly affected by diabetes and were found at 2.72 mm for diabetic subjects, compared to 1.29 mm for controls. The proposed setup can therefore be considered a valuable tool for effective diagnosis of diabetes.   Keywords: Diabetes, Diabetic neuropathy, Horizontal deviation, Interface, Movement time, Skew.