Chronic low-grade inflammation is a hallmark of type 2 diabetes mellitus (T2DM), contributing to insulin resistance and various metabolic complications. Pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6) are key mediators of diabetes-induced inflammation. Natural compounds like Curcuma longa, known for their anti-inflammatory and antioxidant properties, offer promising therapeutic potential with fewer side effects than synthetic drugs.